Peer Reviewed Journal
2025, Vol. 5, Issue 1, Part A
Development of sustained release matrix tablet of diclofenac sodium
Author(s): Anurag, Nidhi Jain and Babita Kumar
Abstract: The main aim of this study is to prepare and evaluate diclofenac sodium sustained-release matrix tablets as a very advanced NSAID in pain and inflammation treatment. The formulation utilizes Hydroxypropyl Methylcellulose (HPMC) as the hydrophilic matrix former controlling drug release, Microcrystalline Cellulose as a binder and filler to provide tablet integrity, and Lactose as a bulking agent to improve compressibility. The matrix tablets were evaluated for pre compression parameters like bulk density, angle of repose and compressibility study etc and post compression parameters like hardness test, disintegration time, friability and in vitro dissolution studies etc. The matrix tablets exhibited a satisfactory release profile that is extended over several hours as being drug released, thus minimizing the frequency of dose administration. The successful application of a matrix system for the delivery of diclofenac sodium actually is being subject to some promising applications toward sustaining pain control with improved bioavailability and fewer side effects in contrast to conventional dosing regimens as such.
Pages: 35-38 | Views: 835 | Downloads: 391
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How to cite this article:
Anurag, Nidhi Jain, Babita Kumar. Development of sustained release matrix tablet of diclofenac sodium. Nat J Pharm Sci 2025;5(1):35-38.
