2024, Vol. 4, Issue 2, Part A
Comparison of keratinized cells and autophagic cells in response to the genotoxic effects of Cisplatin: A comprehensive study
Author(s): Sudeshna Sengupta and Dr. Malavika Bhattacharya
Abstract: HNSCC is a complicated type of disease with a multifactorial etiology, Human papillomavirus affects the most it can be of two subgroup types HPV positive and HPV negative. Development and progression of the cancer depends upon some oncogenes, also survival rate analysis can be done by determining cohorts, therefore comprehensive medication is implemented with success. This report specifically discusses the role of epigenetic modifications, HPV positive HNSCC mostly occurs in Latino white men in the United States, and HPV negative has been reported in sublingual sites of OSCC, especially in men. Scope: Now the era depends upon diagnostic markers which help to identify the disease in an early stage and also help to increase the survival rate of patients. Suppose the potential set of genes can be identified and their further pathway enrichment analysis can be done. In that case, those modifications significantly affect carcinogenesis (P53, Rb gene), According to immunohistochemical biopsy of oral dysplastic cells. In this research study through various bioinformatics tools, we can highlight the genotoxic effect of a popular oral cancer drug, Cisplatin on the cellular components and also how the normal non-malignant cells and malignant cells show the gene activities based on keratinization, autophagy, and apoptosis. Results: In the conclusion portion, we can depict that NES and CSDE1 can be good for immunotherapy because they show immunoreactivity with Vimentin (VIM) mitotic Ki67 colocalized, and through restricting VSV regulation. oncolytic virotherapy is the greatest choice nowadays.
Pages: 52-69 | Views: 143 | Downloads: 56
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How to cite this article:
Sudeshna Sengupta, Dr. Malavika Bhattacharya. Comparison of keratinized cells and autophagic cells in response to the genotoxic effects of Cisplatin: A comprehensive study. Nat J Pharm Sci 2024;4(2):52-69.