Peer Reviewed Journal
2024, Vol. 4, Issue 2, Part A
Formulation and Evaluation of sustained release ocular insert for Acetazolamide
Author(s): VR Sangale, PY Patil, MA Khambalkar, HD Jedage and SG Salunke
Abstract: The present research work explores the development of a novel drug delivery system for the treatment of ocular conditions, with a focus on glaucoma management. Glaucoma, a leading cause of irreversible blindness worldwide, often requires long-term medication to control intraocular pressure and prevent optic nerve damage. However, conventional eye drop formulations pose challenges such as poor patient compliance and fluctuating drug levels. In response, sustained-release ocular inserts of Acetazolamide offer a promising alternative by providing controlled drug release over an extended period, leading to improved therapeutic outcomes and patient convenience. This thesis investigates the formulation parameters and optimization techniques for developing acetazolamide-loaded ocular inserts using biocompatible polymers. The Ocular Inserts of Acetazolamide were formulated using solvent casting method. Ocular Inserts formulations composed of different ratios of HPMC, EC, Chloroform (CHL) and Dichloromethane (DCM) were casted on a glass slab using glass rings. Various evaluation test methods, including physicochemical evaluation, drug content, in vitro drug release studies etc. assessments, are employed to assess the performance and efficacy of the developed inserts. The developed ocular inserts of Acetazolamide showed satisfactory properties like thickness, weight, tensile strength, folding endurance, flatness, etc. Batch (B3) was selected as best batch and showing all the test results satisfactory. The in vitro release of ocular Inserts film showed release in the range 70.00 % - 88.04 %. The findings contribute to advancingocular drug delivery technology, with implications for enhancing treatment efficacy and patient adherence in glaucoma management.
Pages: 26-36 | Views: 323 | Downloads: 134
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How to cite this article:
VR Sangale, PY Patil, MA Khambalkar, HD Jedage, SG Salunke. Formulation and Evaluation of sustained release ocular insert for Acetazolamide. Nat J Pharm Sci 2024;4(2):26-36.
