National Journal of Pharmaceutical Sciences
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P-ISSN: 2788-9262, E-ISSN: 2788-9270

2024, Vol. 4, Issue 2, Part A


Formulation and development of catechin based nanogel for gingivitis


Author(s): MA Khambalkar, PY Patil, MN Kapashikar, HD Jedage and VR Sangale

Abstract: This thesis focuses on the formulation and development of a novel catechin-based nanogel for the targeted delivery of catechin hydrate to gingival tissues, aiming to address the limitations of conventional therapies in gingivitis management. Nanogel formulation was formulated using Carbopol 934 and Poloxamer 407 polymers, was meticulously designed to encapsulate catechin hydrate efficiently and ensure sustained release kinetics in the oral cavity. The Nanogel was evaluated for its Homogeneity, pH, Spreadability, Particle size & Zeta potential, Viscosity, In- vitro release study and stability profile of the catechin-based nanogel formulation through a series of in vitro experiments and analyses. The in vitro release of Catechin hydrate Nanogel was observed in the range of 83.746%- 94.846%. Initial burst release studies revealed rapid onset of therapeutic action, followed by sustained release kinetics, maintaining therapeutic levels of catechin hydrate over an extended period. Moreover, the stability study conducted over a three- month period confirmed the robustness and integrity of the nanogel formulation. The developed formulation exhibited favorable properties, including uniform particle size distribution, mucoadhesive properties, and compatibility with oral tissues.

Pages: 16-25 | Views: 197 | Downloads: 68

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National Journal of Pharmaceutical Sciences
How to cite this article:
MA Khambalkar, PY Patil, MN Kapashikar, HD Jedage, VR Sangale. Formulation and development of catechin based nanogel for gingivitis. Nat J Pharm Sci 2024;4(2):16-25.


National Journal of Pharmaceutical Sciences

National Journal of Pharmaceutical Sciences

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