2024, Vol. 4, Issue 1, Part A
Design and synthesis of pyrimidine derivatives as potent EGFR inhibitors for non-small cell lung cancer
Author(s): GL Bakare and IO Yisa
Abstract: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality globally. Epidermal growth factor receptor (EGFR) is frequently overexpressed in NSCLC, making it a critical target for therapeutic intervention. This study aims to design and synthesize novel pyrimidine derivatives and evaluate their efficacy as EGFR inhibitors. Through a combination of computational modeling, chemical synthesis, and biological assays, we identify several potent pyrimidine-based compounds with significant inhibitory activity against EGFR. These findings present a promising avenue for developing new treatments for NSCLC.
Pages: 45-47 | Views: 288 | Downloads: 144
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How to cite this article:
GL Bakare, IO Yisa. Design and synthesis of pyrimidine derivatives as potent EGFR inhibitors for non-small cell lung cancer. Nat J Pharm Sci 2024;4(1):45-47.