2023, Vol. 3, Issue 2, Part A
Phytochemical analysis, antipyretic and antifungal activities of Solanum nigrum L.
Author(s): Lubna Shakir, Shakir Ullah, Mohammad Sohail and Rihan Ullah Muhammad Sajid
Abstract: Medicinal plants contain chemical compounds capable of preventing and fighting oxidative related diseases. In the present study phytochemical analysis of ethanolic, methanol, and chloroform extracts and anti-pyretic, antifungal activities in methanolic, ethanolic and chloroform extracts of Cyrtomium caryotideum, were carried out. Phytochemical analysis showing that ethanolic and methonalic extract contained carbohydrates, flavonoids, alkaloids, phlobatannins, saponins, tannins, phenols, terpenoids and cardiac glycosides, while alkaloids, phlobatannins, glycosides and protein were absent. Quantative phytochemistry showed the presence of flavonoids in chloroform extract as (14.20±0.15 mg/ml), while alkaloids as (12.10±0.15 mg/ml), phenolic as (10.45±0.10 mg/ml), Saponins (06.22±0.14 mg/ml) and Tannins as (04.60±0.65 mg/ml). Pharmacological activities such as, Anti-pyretic activity were carried out by brewer yeast induced pyrexia. Dose of 600 mg/kg of extract showed significant anti-pyretic activity i.e. (59.43%) when compared with positive control paracetamol i.e. (37.24 °C) inhibition (73.23%). Antifungal activity showing the most active among the extracts range from (17.00±0.48 mm) zone of inhibition at the concentration of18 mg/µl against Verticillium followed by Pythium range from (16.27±0.93 mm), Acremonium (16.20±1.89 mm) and Trichoderma (16.11±0.82) with concentration of 12 mg/µl.
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How to cite this article:
Lubna Shakir, Shakir Ullah, Mohammad Sohail, Rihan Ullah Muhammad Sajid. Phytochemical analysis, antipyretic and antifungal activities of Solanum nigrum L.. Nat J Pharm Sci 2023;3(2):06-12.