Peer Reviewed Journal
2023, Vol. 3, Issue 2, Part A
Experimental and preclinical investigations of Helicteres isora extracts in drug discovery
Author(s): Binod Thapa
Abstract: Helicteres isora L. (Avartani; Sterculiaceae) is a plant with significant ethnopharmacological value, traditionally used for treating a variety of ailments. Recent studies have explored its pharmacological potential in drug discovery, particularly in the areas of metabolic diseases, hepatoprotective effects, anti-inflammatory activity, antioxidant properties, and its potential for combating infections. This paper reviews the experimental and preclinical investigations of H. isora extracts across various biological models, focusing on its antidiabetic, antihyperlipidemic, hepatoprotective, anti-inflammatory, and antioxidant properties. The reviewed studies indicate that aqueous and alcoholic extracts from different parts of the plant, including the bark, fruit, and root, exhibit beneficial effects in animal models of disease. These include improving glycemic control, lipid profiles, and fatty acid composition in diabetic rats, offering hepatoprotection in liver injury models, and demonstrating significant anti-inflammatory and antidiarrheal effects. Preliminary evidence also suggests antiviral and neurobehavioral benefits, warranting further investigation. Although the findings are promising, challenges such as variation in extraction methods and the need for consistent standardization limit the translation of these results into clinical applications. Further studies focusing on bioactive compound isolation, pharmacokinetics, and toxicity are crucial for advancing H. isora as a potential therapeutic agent.
Pages: 82-85 | Views: 398 | Downloads: 151
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How to cite this article:
Binod Thapa. Experimental and preclinical investigations of Helicteres isora extracts in drug discovery. Nat J Pharm Sci 2023;3(2):82-85.
