National Journal of Pharmaceutical Sciences
2022, Vol. 2, Issue 2, Part A
Author(s): Manav Jadav, Dr. Jitendra Patel and Dr. Umesh Upadhyay
Abstract: Excipients are crucial for creating a dosage form. These are the components that make up the dosage forms, together with the active pharmaceutical components. The following overview addresses the many types and sources of excipients along with their purposes, and they can be employed for diverse activities. Excipients operate as protective agents, bulking agents, and can also be used to increase bioavailability of medications in particular situations. The selection criteria for excipients and numerous interactions that an excipient can experience throughout the length of its stay in formulation have been covered in this review. Particular excipients are better suited for a specific dosage form. There are several excipient interactions that can be harmful and should be avoided. The interaction section contains further information about this. Excipients, like other active pharmaceutical substances, must be stabilized and standardized; the following study provides a brief overview of these processes as well as the excipients' safety evaluation criteria. Excipients are crucial for creating dosage forms. Excipients serve a variety of purposes in pharmaceutical dosage forms, including aiding with disintegration, lubrication, binding, and suppliers as well as increasing active substances in dosage forms. Each excipient has unique properties. An extensive list of studies on the purpose and makeup of solid excipients in solid dosage forms is provided in this study. Different compositions might employ a variety of options, therefore the difference will also change. Describe the many types of excipients that may be used for different solid preparation components in this example. Choose the appropriate type of excipient based on the required solid preparation's characteristics. A method for mixing and characterising solid excipients to determine their quality was also described in this review. Low properties, compressibility index, Hausner index ratios, and angle of repose are the most used techniques for analysing solid excipients. Even though Fourier transform infrared spectroscopy (FTIR), H and CNucleo magnetic resonance (H-CNMR), scanning electron microscopy (SEM), Particle size analysis (PSA), X-ray diffraction (XRDP), and differential scanning calorimeter are among the instruments often employed (DSC).
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How to cite this article:
Manav Jadav, Dr. Jitendra Patel, Dr. Umesh Upadhyay. Pharmaceutical excipients. Nat J Pharm Sci 2022;2(2):24-36.