2022, Vol. 2, Issue 2, Part A
Nanosuspension: A favourable viewpoint for drug delivery of poorly soluble drugs
Author(s): Chirag Rathva, Nensi Raytthatha and Umesh Upadhyay
Abstract: Many recently produced medications have weak solubility, which causes significant issues during formulation and exhibits poor bioavailability. The issue is significantly more complicated for medications that fall under BCS Class II. Nanotechnology is utilised to increase the solubility and bioavailability of poorly soluble medications in order to solve these issues. The definition of nanotechnology is the use of science and engineering at the Nano scale, or 10-9 metres. Nanotechnology includes Nanosuspensions. As defined by surfactants and polymers, Nanosuspensions are submicron colloidal dispersions of pharmaceutical active component particles in a liquid phase, below 1 m in size, without any matrix material. Nanosuspensions are different from nanoparticles and solid lipid nanoparticles in that they are lipid carriers of medications whereas nanoparticles are polymeric colloidal carriers of pharmaceuticals. All medications that are insoluble in water may be prepared as Nanosuspension, which is a straightforward process. Wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification, and supercritical fluid processes are used to create Nanosuspensions. Delivery methods for Nanosuspensions include oral, parenteral, pulmonary, and ocular. By including Nanosuspensions in mucoadhesive hydrogels and ocular inserts, tailored medication delivery is also possible. In addition to addressing the issues of low solubility and bioavailability, Nanosuspensions also change the pharmacokinetics of the medicine, enhancing its safety and effectiveness.
Pages: 13-23 | Views: 300 | Downloads: 171
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How to cite this article:
Chirag Rathva, Nensi Raytthatha, Umesh Upadhyay. Nanosuspension: A favourable viewpoint for drug delivery of poorly soluble drugs. Nat J Pharm Sci 2022;2(2):13-23.