National Journal of Pharmaceutical Sciences
2022, Vol. 2, Issue 1, Part A
Preparation and characterisation of anti-diabetic tablet containing p-GP inhibitors and herbal ingredients
Author(s): Isha Shah, Jigar Vyas and Nensi Raytthatha
Abstract: Objective: The objective of the present research work was to develop antidiabetic formulation containing natural P-GP inhibitors in order to increase the Metformin drug permeability and a natural binder with an anti-diabetic effect.Result: From the data it was concluded that F4 batch (Piperine 250mg) was optimized for further study as it shows complete release with higher permeation in less time than marketed and F1-F3 batches with a significant difference in percentage drug permeation. The optimized batches (F5-F8) were prepared, and their evaluation was carried out. After evaluating all parameters, it was observed that batch F8 (Linseed 15% and Dates 15%) was selected for stability study as all the parameters are found to be within their acceptable range, in compliance with IP standards. Conclusion: The current study reveals that piperine in a suitable proportion can be highly effective in increasing the permeability of Metformin and incorporation of herbal ingredient can reduce its side effects.
Pages: 54-57 | Views: 191 | Downloads: 96
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How to cite this article:
Isha Shah, Jigar Vyas, Nensi Raytthatha. Preparation and characterisation of anti-diabetic tablet containing p-GP inhibitors and herbal ingredients. Nat J Pharm Sci 2022;2(1):54-57.