National Journal of Pharmaceutical Sciences
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P-ISSN: 2788-9262, E-ISSN: 2788-9270

National Journal of Pharmaceutical Sciences


2022, Vol. 2, Issue 1, Part A
Formulation and in vitro evaluation of bilayer floating tablet of Aceclofenac and esomeprazole by using natural and synthetic polymer


Author(s): Rajia Sultana Nijhu, Ambia Khatun and Md. Abdul Mannan

Abstract: The goal of this study was to create bilayer floating tablets containing Aceclofenac and Esomeprazole. OTC analgesics, such as NSAIDs, are widely used, but they are commonly misused and possibly harmful, and users are often uninformed of the potential for negative side effects. It is made up of a floating Esomeprazole instant release layer and a sustained release Aceclofenac layer created utilizing the direct compression approach. Sodium starch glycolate super disintegrants were used to create six floating instant release layer formulations containing Esomeprazole (F1–F6). Natural and synthetic release retarding polymers (Xanthangum, HPMC E15, HPMC K100M, HPMC E5) at three different doses, as well as additional additives, were used to make six formulations of sustained release layer containing Aceclofenac (F1–F6). The floating instant release layer recipe was designed to release the largest amount of Esomeprazole possible. The sustained release formulation (F3) released 98 percent of the Aceclofenac in 6 hours, had a 48-second buoyancy lag, and was floatable throughout the experiments. The amount of medication released was inversely related to the amount of polymer present. An FTIR analysis found no chemical interactions between the medication and the polymers utilized. Gastric ulcers affect 10-20% of people who take nonsteroidal anti-inflammatory drugs (NSAIDs). This Aceclofenac and Esomeprazole bilayer floating tablet is suitable for treating pain and inflammation, as well as controlling NSAID-induced ulcers.

Pages: 33-43 | Views: 129 | Downloads: 64

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How to cite this article:
Rajia Sultana Nijhu, Ambia Khatun, Md. Abdul Mannan. Formulation and in vitro evaluation of bilayer floating tablet of Aceclofenac and esomeprazole by using natural and synthetic polymer. Nat J Pharm Sci 2022;2(1):33-43.


National Journal of Pharmaceutical Sciences