National Journal of Pharmaceutical Sciences
2021, Vol. 1, Issue 1, Part A
A review of pyrazole an its derivative
Author(s): Bhawna Poudyal and Bharghav G
Abstract: Pyrazole is a 2-neighbour nitrogen containing 5-membered heterocyclic organic compound with three carbon atoms. Pyrazole commonly known as 1,2 diazoles has been very popular now a days due to manifold uses. There are number of pyrazole derivative which has broad spectrum of biological activities like anti-bacterial, anti-microbial, anti-inflammatory, anti-convulsant, analgesic, anti-diabetic, anti-rheumatic, anti-cancer, and anti- tuberculosis. There are several applications of pyrazole core based organic molecules in various areas including pharmacy and agro-chemical industries. There is various method used for manufacture of pyrazole and its derivative. The purpose of the review was to collect various pharmacological actions which was reported in recent years made on its moiety. Pyrazole and its derivatives are prepared by dehydrogenating 2-pyrazoline or its derivative by process in which the reaction is carried out using sulfuric acid in the presence of iodine or of an iodine compound. Taking into considerations diversity in the biological activity, this nucleus has attracted attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Development of pyrazole an its derivative has been reported by many scientists in decades.
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How to cite this article:
Bhawna Poudyal, Bharghav G. A review of pyrazole an its derivative. Nat J Pharm Sci 2021;1(1):34-41.